Jose Leonardo (Onard) Mejino Jr. MD

DEGREES

B.S., General Science, University of Santo Tomas, Manila, Philippines, 1977
M.D., University of Santo Tomas, Manila, Philippines, 1981

RECENT POSITION

Senior Research Scientist (2001-2019),
Structural Informatics Group, Department of Biological Structure, School of Medicine, University of Washington, Seattle

POSTGRADUATE

Makati Medical Center, Makati, Philippines: Intern, 1981-82
Perpetual Succor Hospital, Manila, Philippines: OB-GYN Pre-resident, 1982-83
University of Washington School of Medicine, Cancer Research Group, Postdoctoral Fellow, 1984-1989

PREVIOUS POSITIONS

Research Scientist 1, Cancer Research Group, Department of Biological Structure, University of Washington, Seattle, 1990-94
Research Scientist 2, Structural Informatics Group, Department of Biological Structure, University of Washington, Seattle, 1996-98
Research Scientist 3, Structural Informatics Group, Department of Biological Structure, University of Washington, Seattle, 1998-2001
Visiting Research Scientist.
National Center for Biomedical Ontology (NCBO), Department of Philosophy, State University of New York (SUNY) at Buffalo and Research Foundation of the State of New York, 2006
Informatics Consultant, Nervana Inc., Bellevue, WA, Aug-Oct 2006
Ontology Consultant, VenLogic Inc, Seattle, WA Feb-Mar 2001
Ontology Consultant, Anatomy Next, 2015-present

PROFESSIONAL AND HONORARY SOCIETIES

American Medical Informatics Association (AMIA)
International Federation of Associations of Anatomists (IFAA)
Philippine Medical Association (PMA)
UST Medical Alumni Association (USTMAA)

EDITORIAL RESPONSIBILITIES

Reviewer, The New Anatomist, The Anatomical Record Journal
Reviewer, BMC Bioinformatics Journal
Reviewer, Journal of American Medical Informatics Association (JAMIA)
Reviewer, Proceedings of American Medical Informatics Association (AMIA)
Reviewer, Frontiers in Neuroscience
Member, Editorial board, Frontiers in Neuroinformatics 2008-present
Reviewer, Journal of Biomedical Informatics (JBI)
Reviewer, Scientific Reports, Nature Research
Reviewer, Dorland’s Medical Dictionary

TEACHING

Gross Anatomy dissection, Medical and Dental Students, University of Washington, 2015-present

Anatomy Ontology (Foundational Model of Anatomy [FMA] Ontology) lecture in MEBI 534 class in Division of Biomedical and Health Informatics, Graduate students, University of Washington, 2008-2016

RESEARCH

Cancer Research: 1983-1994
Cell production and cell differentiation in the immune and hematopoietic systems
Biomedical Informatics: 1996 to present
Knowledge representation in anatomy (spatial and symbolic)
Ontology framework and content development for multidisciplinary biomedical domains
Common Anatomy Reference Ontology (CARO)
Foundational Model of Anatomy (FMA)
Foundational Model of Neuroanatomy (NeuroFMA)
Ontology of Craniofacial Development and Malformation (OCDM)
Radiology Lexicon (RadLex)
Ontology of Physics for Biology (OPB)
Pathology Reference Ontology (PathRO)
Virtual Soldier Knowledge Base (VSKB)
Virtual Physiologic Human (VPH) anatomy axis.
Application ontologies for
Acute respiratory distress syndrome (ARDS)
Radiological image findings
Dental consultation
Immunology
NeuroImaging
Head and neck radiation treatment planning
Ontology federation and integration
Ontology alignment
FMA-SNOMED CT mappings
Development of anatomy ontology language format for the semantic web
Computer-based applications for biomedical education and clinical practice
On-line information resources and interfaces for anatomy
Medical image segmentation and annotation

SERVICE

Professional:

Consultant
Visible Embryo Project, Oregon Health Sciences University, 1999
Dental School Informatics, University of Washington, 1999-2012
Craniofacial Malformation Research, Children’s Orthopedic Hospital, 2002
MedOrder Inc., 2003
Nervana Inc., 2006
VenLogic Inc., 2007
Anatomy Next, 2015-present

Participant
Kaiser Permanente terminology/ontology workshop, University of Washington School of Medicine, 1999
Digital Human Project, Federation of American Scientists, 2002-2004
SAEL-SOFG Anatomy Resource, 2004
Terminologia Anatomica Working Group, Federative International Committee on Anatomical Terminology (FICAT), 2005-present
Neuroanatomy ontology workshop, Human Brain Project, NIH, 2006
Image ontology workshop, NCBO, Stanford University, 2006
Immunology ontology workshop, Division of Allergy, Immunology and Transplantation (DAIT), NIAID, 2006
Advance team, Anatomy ontology workshop, NCBO,
University of Washington, 2006

Scientific Committee Member
National Center for Ontological Research (NCOR), 2005
State University of New York at Buffalo
Stanford University
Knowledge Representation in Medicine (KR-MED) AMIA Working Group, 2005-2011
Federative International Committee on Informatics in Anatomy (FICIA), 2004-2010
Programs on Ontologies for Neural Structures (PONS), International Neuroinformatics Coordinating Facility (INCF), 2009-2011
International Conference on Biomedical Ontology (ICBO), 2009-2014
Bio-ontologies SIG, Intelligent Systems for Molecular Biology (ISMB), 2010-2011
Federative International Programme for Anatomical Terminology (FIPAT), International Federation of Associations of Anatomists (IFAA), 2017-present

Referree/Reviewer
Grant reviewer, Bioengineering Research Partnership (BRP), National Institute of Health (NIH), 2006

SELECTED INVITED PRESENTATIONS

1999 Role of Anatomy in Biomedical Informatics. Far Eastern University School of Medicine, Manila, Philippines.
2001 An educational symposium: How do we teach anatomy to the computer? American Association of Clinical Anatomists, Nashville, TN. June.
2004 How do we associate FMA concepts with neoplasia? National Cancer Institute Center for Bioinformatics, Bethesda, MD, March.
2004 Symbolic modeling of structural relationships in the Foundational Model of Anatomy. First International workshop on Formal Biomedical Knowledge Representation, Whistler Mountain, B.C. Canada, June.
2005 A Theory of Anatomical Boundary and its Implementation in the Foundational Model of Anatomy. Mapping the Human Body Workshop, State University of New York at Buffalo, NY, April.
2005 Representation of Neuroanatomy in the Foundational Model of Anatomy. The Human Brain Project, NIH, Bethesda, MD, April.
2005 The Digital Anatomist Foundational Model of Anatomy. 8th International Protégé Conference, Madrid, Spain, July.
2006 The Foundational Model of Anatomy: Ontology Building Block. Immunology Ontology Workshop, Division of Allergy, Immunology and Transplantation (DAIT), NIAID, Gaithersburg, MD, March
2006 The Virtual Human: the ultimate body double. University of Santo Tomas (UST) Faculty of Medicine and Surgery PostGrad CME, Manila, Philippines.
2007 The NeuroFMA: Ontology Framework for Neuroanatomy. Ontology View Grant Meeting, Stanford University, Palo Alto, CA.
2008 The Foundational Model of Anatomy (FMA) Ontology: Framework for Cellular and Subcellular Anatomy. NCBO Workshop on Ontologies of Cellular Networks. Newark, NJ.
2009 The Foundational Model of Anatomy (FMA) Ontology: Ontological Framework for Data Harmonization and Interoperability. Virtual Physiological Human Meeting, European Bioinformatics Institute (EBI), Hinxton, England.
2009 FMA in OWL 2. NCBO Dissemination meeting, Stanford University, Palo Alto, CA
2010 Foundational Model of Neuroanatomy: NeuroFMA. Programs on Ontologies for Neural Structures (PONS), INCF Task Force meeting, Pilsen, Czech Republic.
2010 The Foundational Model of Anatomy (FMA) Ontology: Framework for Cell Classification. Cell Ontology Workshop, Bar Harbor, Maine.
2011 Ontology of Craniofacial Development and Malformation: Cleft lip and palate classification. University of Southern California (USC), Los Angeles, CA
2012 FMA-RadLex alignment. RSNA-NIBIB meeting, Stanford University, Palo Alto, CA
2013 Human Development Domain of the Ontology of Craniofacial Development and Malformation. ICBO meeting, Montreal, Quebec, Canada.
2016 FMA framework for simulation models. Center for Research in Education and Simulation Technologies (CREST) UW, Seattle WA
2017 The Foundational Model of Anatomy (FMA) Ontology: Ontological framework for Data Integration. Neurogenic Summit 2017, Seattle, WA

PUBLICATIONS

Journal articles

1. Farr AG, Anderson SK, Baddy SC, Mejino JLV. 1988. Selective binding of Dolichos biflorus agglutinin to L3T4-, Lyt-2- thymocytes. Expression of terminal alpha-linked N-acetyl-D-galactosamine residues defines a subpopulation of fetal and adult murine thymocytes. J Immunol. Feb 15;140(4):1014-21.

2. Mejino JLV, Lee MY, Hamilton BH, and Rosse C. 1991. The role of hematogenous and intrinsic precursor cells in lymphocyte production in murine bone marrow and thymus. Am. J. Anat. 192: 232-240.

3. Rosse C, Mejino JL, Modayur BR, Jakobovits R, Hinshaw KP, Brinkley JF. 1998. Motivation and organizational principles for anatomical knowledge representation: the Digital Anatomist Symbolic Knowledge Base. J. Am. Med. Informatics Assoc.5:17-40.

4. Mejino, JL and Rosse C. 1998. The Potential of the Digital Anatomist Foundational Model for assuring consistency in UMLS sources. IN Chute EG (ed): A paradigm shift in health care information systems: clinical infrastructures for the 21st century. JAMIA Symposium Supplement. '98:825-829

5. Mejino, JLV and Rosse C. 1999. Conceptualizations of Anatomical Spatial Entities in the Digital Anatomist Foundational Model. J. Am. Med. Assoc. AMIA ’99 Symp. Suppl. '99: 112-116.

6. Agoncillo, A, Mejino JLV, 1999. Rosse C. Influence of the Digital Anatomist Foundational Model on Traditional Representations of Anatomical Concepts. J. Am. Med. Assoc. AMIA ’99 Symp. Suppl. '99: 2-6.

7. Michael J, Mejino JLV, Rosse C. 2001. The role of definitions in biomedical concept representation. JAMIA Symposium Supplement. '01:463-467.

8. Martin RF, Mejino JLV, Bowden DM, Brinkley JF, Rosse C. 2001. Foundational model of neuroanatomy: its implications for the Human Brain Project. JAMIA Symposium Supplement. '01:438-442.

9. Rosse C, Mejino JLV Jr. 2003. A reference ontology for bioinformatics: the Foundational Model of Anatomy. J Biomed Inform. 36:478-500.

10. Mejino JLV Jr, Agoncillo AV, Rickard KL, Rosse C. 2003. Representing complexity in part-whole relationships within the Foundational Model of Anatomy. Proc AMIA Symp. p.450.

11. Cook DL, Mejino JLV Jr, Rosse C. 2004. Evolution of a Foundational Model of Physiology: Symbolic Representation for Functional Bioinformatics. In Proceedings: MedInfo 2004 pp 336-340, San Francisco, CA.

12. Rickard KL, Mejino JLV Jr, Martin RF, Agoncillo AV, Rosse C. 2004. Problems and Solutions with Integrating Legacy Terminologies into Evolving Knowledge Bases. In Proceedings: MedInfo, pp 420-424, San Francisco, CA .

13. Detwiler LT, Chung E, Li A, Mejino JLV Jr, Agoncillo AV, Brinkley JF, Rosse C. 2004. A Relation-Centric Query Engine for the Foundational Model of Anatomy. In Proceedings: MedInfo, pp341-345, San Francisco, CA.

14. Noy, NF, Mejino JLV, Musen MA and C. Rosse. 2004. ‘Pushing the envelope: challenges in frame-based representation of human anatomy’. Data &Knowledge Engineering 48:335-359.

15. Mejino JLV Jr, Rosse C. 2004. Symbolic modeling of structural relationships in the Foundational Model of Anatomy. In Proceedings: First International Workshop on Formal Biomedical Knowledge Representation (KR-MED 2004), Whistler Mountain, B.C., Canada; pp 48-62.

16. Cook DL, Mejino JLV, and Rosse C. 2004. The Foundational Model of Anatomy: a template for the symbolic representation of physiological functions. Conf Proc IEEE Eng Med Biol Soc. 2004;7:5415-8.

17. Shapiro L, Chung E, Detwiler LT, Mejino JLV, Agoncillo AV, Brinkley JF and Rosse C. 2005. Processes and problems in the formative evaluation of the Foundational Model of Anatomy knowledge base. J. Am. Med. Informatics Assoc 12(1):35-46.

18. Smith B, Mejino JLV, Schulz S, Kumar, A and Rosse C. 2005. Anatomical information science. COSIT ’05, pp.149-164, Ellicottville, New York.

19. Rosse C, Kumar A, Mejino JLV, Cook DL, Detwiler LT, and Smith B. 2005. A strategy for improving and integrating biomedical ontologies. Proc. AMIA Symp 2005, Washington DC.

20. Rosse C, Mejino JLV. 2008. The Foundational Model of Anatomy Ontology. in: Burger A, Davidson D, Baldock R. (eds.), Anatomy Ontologies for Bioinformatics: Principles and Practice, New York: Springer, 2008. pp 59-117

21. Mejino JLV, Rubin DL, Brinkley JF. 2008. FMA RadLex: An Application Ontology of Radiological Anatomy derived from the Foundational Model of Anatomy Reference Ontology. Proc. AMIA Symp 2008:465-469.

22. Cook DL, Mejino JLV, Neam ML and Gennari JH. 2008. Bridging Biological Ontologies and Biosimulation: The Ontology of Physics for Biology. Proc AMIA Symp. pp136-140.

23. Kalet I, Mejino JLV, Wang V, Whipple M and Brinkley JF. 2009. Content-specific auditing of large scale anatomy ontology. J Biomed Inform 42(3):pp 540-549.

24. Gu H, Wei D, Mejino JLV, Elhanan G. 2009. Relationship auditing of the FMA Ontology. J. Biomed. Inform. Vol 42, Issue 3, pp 550-557.

25. Turner JA, Mejino JLV, Brinkley JF, Detwiler LT, Lee HJ, Martone ME and Rubin DL. 2010. Application of neuroanatomical ontologies for neuroimaging data annotation. Frontiers in Neuroinformatics 4(10), 1-12

26. Puget A, Mejino JLV, Detwiler LT, Franklin JD, Brinkley JF. 2012. Spatial-symbolic query engine in anatomy. Methods of Information in Medicine 51(6): 463-478.

27. Steinert-Threlkeld S, Ardekani S, Mejino JLV, Detwiler LT, Brinkley JF, Halle M, Kikinis R, Winslow RL, Miller MI, Ratnanather JT. 2012. Ontological labels for automated location of anatomical shape differences. J Biomed Inform. 2012 Jun;45(3):522-7. doi: 10.1016/j.bi.2012.02.013.

28. Zhang GQ, Luo L, Ogbuji C, Joslyn C, Mejino J, Sahoo SS. 2012. An analysis of multi-type relational interactions in FMA using graph motifs with disjointness constraints. AMIA Annu Symp. Proc. 2012;2012:1060-9.

29. Mejino JLV, Travillian, RS, Cox, TC, Shapiro, LG, Brinkley JF. 2013. Human development domain of the Ontology of Craniofacial Development and Malformation. CEUR Workshop Proc. 2013 July;1060: 74–77. PMID: 28261023.

30. Luo L, Mejino JLV, Zhang GQ. 2013. An analysis of FMA using structural self-bisimilarity. J Biomed Inform. 2013 Jun;46(3):497-505. doi: 10.1016/j.bi.2013.03.005.

31. Brinkley JF, Borromeo C, Clarkson M, Cox TC, Cunningham MJ, Detwiler LT, Heike CL, Hochheiser H, Mejino JLV, Travillian RS and Shapiro LG. 2013. The Ontology of Craniofacial Development and Malformation for Translational Craniofacial Resarch. AM J Med Genet C Semin Med Genet.2013 Nov;163C(4):232-45. doi: 10.1002/ajmg.c.31377.

32. Brinkley JF, Mejino JLV, Detwiler LT, Travillian RS, Clarkson M, Cox T, Heike C, Cunningham M, Hochheiser H and Shapiro LG. 2013. Towards understanding craniofacial abnormalities: the ontology of Craniofacial Development and Malformation. AMIA Jt. Summits Transi Sci.Proc. 2013 Mar 18;2013:20

33. Wang KH, Heike CL, Clarkson MD, Mejino JLV, Brinkley JF, Tse RW, Birgfeld CB, Fitzsimons DA and Cox TC. 2014. Evaluation and integration of disparate classification systems for clefts of the lip. Front Physiol.2014 May 14;5:163. doi: 10.3389/fphys.2014.00163.

34. Nolan NB, Mejino JLV, Detwiler LT, Nilsen TT, Martone ME, Turner JA, Rubin DL, Brinkley JF. 2014. Neuroanatomical domain of the Foundational Model of Anatomy ontology. J. Biomed. Semant., 5:1 (doi:10.1186/2041-1480-5-1)

35. Wang KC, Salunkhe AR, Morison JJ, Lee PP, Mejino JLV, Detwiler, LT, Vrinkley JF, Siegel EL, Rubin DL and Carrino JA. 2015. Ontology-based image navigation: exploring 3.0-T MR neurography of the brachial plexus using AIM and RadLex. Radiographics. 2015 Jan-Feb;35(1):142-51. doi: 10.1148/rg.351130072

36. Mejino JLV Jr, Detwiler LT, Cox TC, Brinkley JF. 2016. Multi-species Ontologies of the Craniofacial Musculoskeletal System. CEUR Workshop Proc. 2016 Aug;1747. pii: http://ceur-ws.org/Vol-1747/IP03_ICBO2016.pdf PMID:28217040

37. Detwiler LT, Mejino JLV, and Brinkley JF. 2016. From frames to OWL 2:Converting the Foundational Model of Anatomy. Artif Intell Med. 2016 May;69:12-21.doi: 10.1016.04.003.

38. Elhanan G, Ochs C, Mejino JLV, Liu H, Mungall CJ, and Perl Y. 2017. From SNOMED CT to Uberon: Transferability of evaluation methodology between similarly structured ontologies. Artif Intell Med. 2017 May 19. Pli: S0933-3657(16)30374-8. Doi: 10.1016/j.artmed.2017.05.002

39. Luo L, Tong L, Zhou X, Mejino JLV, Ouyang C and Liu Y. Evaluating the granularity balance of hierarchal relationships within large biomedical terminologies towards quality improvement. J. Biomed Inform 2017;75:129-137.

40. Jung H, Law A, Grunblatt E, Wang LL, Kusano A, Mejino JLV, Whipple ME. 2017. Development of a Novel Markov Chain Model for the Prediction of Head and Neck Squamous Cell Carcinoma Dissemination. AMIA Annu Symp. Proc 2017 Feb 10;2016:1832-1839.

ABSTRACTS

1. Mejino Jr., J. L. V. and C. Rosse 1990 Thymocyte lineages derived from hematogenous and intrinsic progenitors. Exp. Hematol. 18: 587

2. Rosse, C., J. L. V. Mejino, Jr. 1990 Thymic regeneration following corticosteroid-induced involution effected by intrathymic T cell progenitors. Exp. Hematol. 18: 585.

3. Rosse, C., Mejino, J.L. and Brinkley, J.F. 1997. The Digital Anatomist Symbolic Knowledge Base: an approach toward standards in anatomical knowledge representation. J. Am. Med. Informatics Assoc.

4. Brinkley JF, Albright EM, Kim S, Mejino JLV, Shapiro LG, Rosse C. 2000. Visible Human, Construct Thyself: The Digital Anatomist Dynamic Scene Generator. In: The Third Visible Human Project Conference Proceedings. Bethesda: NLM, 27-28.

5. Rosse C, Mejino JLV, Shapiro LG, Brinkley JF. 2000. Visible Human, Know Thyself: The Digital Anatomist Structural Abstraction. In: The Third Visible Human Project Conference Proceedings. Bethesda: NLM; 85-86.

6. Mejino JLV, Noy NF, Musen M, Rosse C. 2001. Representation of structural relationships in the Foundational Model of anatomy. JAMIA Symposium Supplement. '01:937p.

7. Martin RF, Mejino JLV Jr, Bowden DM, Brinkley JF, Rosse C. 2001. A next-generation knowledge source: foundational model of neuroanatomy. Soc.Neurosci. Abstr., Vol. 27, Program No. 23.48p.

8. Rosse C, Mejino JLV. 2001. The Foundational Model of anatomy. Clin Anat. 14:463.

9. Agoncillo AV, Mejino JLV, Rosse C. 2001. Correlation of the Foundational Model with traditional sources of anatomical knowledge. Clin Anat. 14:453p.

10. Mejino JLV, Rosse C. 2001. Anatomical relationships in the Foundational Model of anatomy. Clin Anat. 14:460p.

11. Agoncillo AV, Mejino JLV, Rickard KL, Detwiler LT, Rosse CR. 2003. Proposed Classification of Cells in the Foundational Model of Anatomy. AMIA Annu Symp Proc. 2003:775.

12. Martin RF, Rickard KL, Mejino JLV Jr, Agoncillo AV, Brinkley JF, Rosse C. 2003. The Evolving Neuroanatomical Component of the Foundational Model of Anatomy. Proc AMIA Annu Symp Proc. 2003:438.

13. Detwiler LT, Mejino JLV, Rosse C, Brinkley JF. 2003. Efficient Web-based Navigation of the Foundational Model of Anatomy. AMIA Annu Symp Proc . 2003:829.

14. Mejino, JLV, Martin RF, Detwiler LT and Brinkley JF. 2007. Challenges in Reconciling Different Views of Neuroanatomy in a Reference Ontology of Anatomy. AMIA Annu Symp Proc. 2007

15. Franklin JD, Mejino JLV, Detwiler, LT and Brinkley JF. 2008. Web Service Access to Semantic Web Ontologies. AMIA Annu Symp Proc. 2008:946.

16. Mejino JLV, Detwiler LT, Turner JA, Martone MA, Rubin DL and Brinkley JF. 2010 Enabling RadLex with the Foundational Model of Anatomy Ontology to Organize and Integrate Neuro-imaging Data. AMIA Annu Symp Proc. 2010:1171.

17. Brinkley JF, Turner JA, Detwiler LT, Mejino JLV, Martone ME, and Rubin DL. 2010. Intelligent Queries over BIRN Data using the Foundational Model of Anatomy and a Distributed Query-based Data Integration System. AMIA Annu Symp Proc. 2010:989.

18. Nichols N, Perlmutter A, Mejino JLV and Brinkley JF. 2010. Representing Neural Connectivity in the Foundational Model of Anatomy Ontology. AMIA Annu Symp Proc.2010

19. Mejino JLV, Shapiro LG, Brinkley JF. 2013. An Ontology for Human Craniofacial Development. Annu Symp Proc. 2013

20, Mejino JLV, Detwiler LT, Brinkley JF. 2015. Ontology of Craniofacial Musculoskeletal System. Annu Symp Proc. 2015

21. Mejino JLV, Detwiler LT, Cox TC, Brinkley JF. Cross-species Mapping of Human and Mouse Craniofacial Structures. Proc. AMIA Symp 2017: 2105.

22. Mejino JLV, Detwiler LT, Cox TC, Cunningham, ML, Brinkley JF. Multi-species Malformation Ontologies. 9th International Conference on Biological Ontology (ICBO) 2018, OHSU.